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Nanoscale Devices for Treatment of Autoimmune and Cardiovascular Diseases

点击[] 时间[ 2018年05月28日 08:39] 发布人[]

报告题目 : Nanoscale Devices for Treatment of Autoimmune and Cardiovascular Diseases

报告时间:2018年5月29日 上午10:00

报告地点:新主楼第二报告厅

报告人简介:

Nicholas A. Peppas教授在生物材料、药物控制释放、生物材料和生物纳米技术方面具有世界领导者的地位,同时也是德克萨斯大学奥斯汀分校生物材料、药物传输和再生医学研究所主任。由于他的研究成果,他被选为美国工程院院士、美国医学院院士、美国艺术与科学院院士,美国国家发明科学院院士、中国工程院外籍院士、法国科学院院士、西班牙皇家科学院院士、雅典科学院院士、国际医学与生物工程科学院院士、德克萨斯医学工程与科学学院院士。他也是中国工程院外籍院士。Peppas是中国生物材料学会的官方期刊“再生生物材料”的主编。他是AAAS、AIChE、APS、ACS、MRS、SFB、BMES、AIMBE、CRS、AAPS和ASEE的成员。他指导了110名博士和大约180名博士后和研究生的研究。在中国,他曾多次主持讲座,并被提名为四川大学、协和医科大学等名誉教授。

报告摘要:

Advanced solutions of a number of biomedical engineering problems require that nanotechnology, advanced biomaterials and molecular biology be used in a synergestic way to achieve targeted, effective vehicle for disease treatment. Engineering the molecular design of intelligent gels/biomaterials by controlling structure, recognition and specificity is the first step in coordinating and duplicating complex biological and physiological processes.  Recent developments in siRNA and protein delivery have been directed towards the preparation of targeted formulations for protein delivery to specific sites, use of environmentally-responsive polymers to achieve pH- or temperature-triggered delivery, usually in modulated mode, and improvement of the behavior of their mucoadhesive behavior and cell recognition.  We address design and synthesis characteristics of novel crosslinked networks capable of protein release as well as artificial molecular structures capable of specific molecular recognition of biological molecules. Molecular imprinting and microimprinting techniques, which create stereo-specific three-dimensional binding cavities based on a biological compound of interest can lead to preparation of biomimetic materials for intelligent drug delivery, drug targeting, and tissue engineering. We have been successful in synthesizing novel glucose- and protein-binding molecules based on non-covalent directed interactions formed via molecular imprinting techniques within aqueous media. We have also developed structurally superior materials to serve as effective carriers for siRNA delivery to combat Crohn disease and ulcerative colitis.

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